RESEARCH

Immunity is shaped by where it lives

We study how immune memory is established, maintained, and shaped within tissues — from cell-intrinsic molecular programs to local immune microenvironments.

01 · MEMORY

Tissue-resident immune memory

We investigate how immune memory is established and maintained in barrier tissues, with a particular interest in tissue-resident B cells and their rapid responses to local reinfection.

IMMUNE MEMORYBRMBARRIER TISSUESLOCAL RECALL

02 · PROGRAM

Molecular programming of B cell fate

We investigate the cell-intrinsic programs that shape the fate and function of tissue-resident memory B cells, with a focus on transcriptional and metabolic regulation.

B CELL FATETRANSCRIPTIONAL PROGRAMSMETABOLISMCELL-INTRINSIC SIGNALING

03 · NICHE

Immune niches & microenvironments

We investigate how distinct tissue microenvironments shape the establishment, maintenance, and quality of tissue-resident immune memory, and why protective B cell memory develops more effectively in some tissues than in others.

TISSUE NICHEMICROENVIRONMENTMYELOID CELLSLOCAL IMMUNITY