Tissue-resident immune memory
We investigate how immune memory is established and maintained in barrier tissues, with a particular interest in tissue-resident B cells and their rapid responses to local reinfection.
Discover the program →LABORATORY OF SKIN & MUCOSAL IMMUNOLOGY
Decoding B cell immunity
at barrier tissues
We investigate how humoral immunity is established, maintained and recalled in tissues during infection, vaccination, and across diverse disease settings.
B cell biologyHUMORAL IMMUNITY
Barrier tissuesLUNG · SKIN · MUCOSA
From mechanism to patientsINFECTION · VACCINATION · DISEASE
Our lab asks a simple question with broad implications:
How does the tissue environment shape the quality of immune memory?
RESEARCH
Where immune memory meets tissue immunity.
Molecular programming of B cell fate
We investigate the cell-intrinsic programs that shape the fate and function of tissue-resident memory B cells, with a focus on transcriptional and metabolic regulation.
Discover the program →Immune niches & microenvironments
We investigate how distinct tissue microenvironments shape the establishment, maintenance, and quality of tissue-resident immune memory, and why protective B cell memory develops more effectively in some tissues than in others.
Discover the program →FEATURED QUESTION
What makes a memory B cell stay?
Tissue residency is more than location. We investigate the molecular programs and local signals that create specialized B cell populations poised for rapid protection.
See our workRESIDENCYMETABOLISMBCR SIGNALINGTISSUE NICHE
PEOPLE
Physician-scientists and immunologists working across disciplines.
Led by JI EUN OH, M.D., Ph.D., the OH Lab is based in the Graduate School of Medical Science & Engineering at KAIST in Daejeon, Korea.
Meet the team →SELECTED WORK
Publications
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA.Science Immunology · 2021↗Migrant memory B cells secrete luminal antibody in the vagina.Nature · 2019↗Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.PNAS · 2016↗
LAB LIFE
Latest news
Outstanding Poster Award
Heeyeon received the Outstanding Poster Award at the Korean Association of Immunologists Spring Meeting. Congrats!
Lab Note Contest Award
Jin Kyum was awarded at the Lab Note Contest supported by Samsung Bioepis. Congrats!
Eunsong starts her Ph.D.
Eunsong started her Ph.D. graduate program.
JOIN THE OH LAB
Curious about how immunity
works in tissues?
We welcome motivated students and postdoctoral researchers interested in B cell biology, tissue immunity and host defense.
Get in touch